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Welcome Baby Avi

Welcome Baby Avi

We would like to welcome baby Avi who was born on May 3rd at 6:50 pm. Congrats to Kedar and Holly Aras on their beautiful baby boy! We can’t wait to meet you!...

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Anna Gams Wins APS Abstract Travel Award

Anna Gams Wins APS Abstract Travel Award

BME doctoral student Anna Gams won The American Physiological Society Abstract Travel Award at the 2018 APS Conference on Cardiovascular, Renal, and Metabolic Diseases: Sex-Specific Implications for Physiology.  The conference was held September 30 – October 3 in...

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Journal Club – #38

Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles Dumitrescu C, Narayan P, Cheng Y, Efimov IR, Altschuld RA Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1131-9...

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Journal Club – #37

Imaging of the atrioventricular node using optical coherence tomography Gupta M, Rollins AM, Izatt JA, Efimov IR J Cardiovasc Electrophysiol. 2002 Jan; 13(1):95...

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Journal Club – #35

Mechanisms of make and break excitation revisited: paradoxical break excitation during diastolic stimulation Nikolski VP, Sambelashvili AT, Efimov IR Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H565-75...

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Journal Club – #34

The mechanisms of the vulnerable window: the role of virtual electrodes and shock polarity Yamanouchi Y, Cheng Y, Tchou PJ, Efimov IR Can J Physiol Pharmacol. 2001 Jan;79(1):25-33...

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Journal Club – #32

Reversal of repolarization gradient does not reverse the chirality of shock-induced reentry in the rabbit heart Cheng Y, Nikolski V, Efimov IR J Cardiovasc Electrophysiol. 2000 Sep;11(9):998-1007...

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Journal Club – #31

Virtual electrode polarization in the far field: implications for external defibrillation Efimov IR, Aguel F, Cheng Y, Wollenzier B, Trayanova N Am J Physiol Heart Circ Physiol. 2000 Sep;279(3):H1055-70...

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Journal Club – #29

Direct evidence of the role of virtual electrode-induced phase singularity in success and failure of defibrillation Efimov IR, Cheng Y, Yamanouchi Y, Tchou PJ J Cardiovasc Electrophysiol. 2000 Aug; 11(8):861-8...

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Journal Club – #27

Virtual electrodes and deexcitation: New insights into fibrillation induction and defibrillation Efimov IR, Gray RA, Roth BJ J Cardiovasc Electrophysiol. 2000 Mar; 11(3):339-53 [PubMed]  ...

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Journal Club – #26

Virtual electrode-induced reexcitation: A mechanism of defibrillation Cheng Y, Mowrey KA, Van Wagoner DR, Tchou PJ, Efimov IR Circ Res. 1999 Nov 26; 85(11):1056-66...

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Journal Club – #25

Evidence of three-dimensional scroll waves with ribbon-shaped filament as a mechanism of ventricular tachycardia in the isolated rabbit heart Efimov IR, Sidorov V, Cheng Y, Wollenzier B J Cardiovasc Electrophysiol. 1999 Nov; 10(11):1452-62...

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Journal Club – #24

Biventricular shocking leads improve defibrillation efficacy Yamanouchi Y, Efimov IR, Mowrey KA, Mazgalev TN, Wilkoff BL Tchou PJ J Cardiovasc Electrophysiol. 1999 Apr; 10(4):561-5...

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Journal Club – #23

Voltage-sensitive dye RH421 increases contractility of cardiac muscle Cheng Y, Van Wagoner DR, Mazgalev TN, Tchou PJ, Efimov IR Can J Physiol Pharmacol. 1998 Dec; 76(12):1146-50...

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Journal Club – #21

Virtual electrode effects in transvenous defibrillation-modulation by structure and interface: evidence from bidomain simulations and optical mapping Entcheva E, Eason J, Efimov IR, Cheng Y, Malkin R, Clayton F J Cardiovasc Electrophysiol. 1998 Sep; 9(9):949-61...

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Journal Club – #20

High-resolution, three-dimensional fluorescent imaging reveals multilayer conduction pattern in the atrioventricular node Efimov IR, Mazgalev TN Circulation. 1998 Jul 7; 98(1):54-7...

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Journal Club – #19

Virtual electrode-induced phase singularity: a basic mechanism of defibrillation failure Efimov IR, Cheng Y, Van Wagoner DR, Mazgalev T, Tchou PJ Circ Res. 1998 May 4; 82(8):918-25...

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Journal Club – #18

Hypoxia and hypothermia enhance spatial heterogeneities of repolarization in guinea pig hearts: analysis of spatial autocorrelation of optically recorded action potential durations. Salama G, Kanai AJ, Huang D, Efimov IR, Girouard SD, Rosenbaum DS J Cardiovasc...

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Journal Club – #17

Relation of the atrial input sites to the dual atrioventricular nodal pathways: crossing of conduction curves generated with posterior and anterior pacing Tchou PJ, Cheng YN, Mowrey K, Efimov IR, Van Wagoner DR, Mazgalev TN J Cardiovasc Electrophysiol. 1997...

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Journal Club – #16

Transmembrane voltage changes produced by real and virtual electrodes during monophasic defibrillation shock delivered by an implantable electrode Efimov IR, Cheng YN, Biermann M,  Van Wagoner DR, Mazgalev TN, Tchou PJ J Cardiovasc Electrophysiol. 1997...

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Journal Club – #15

Effects of 2,3-butanedione monoxide on atrial-atrioventricular nodal conduction in isolated rabbit heart Cheng Y, Mowrey K, Efimov IR, Van Wagoner DR, Tchou PJ, Mazgalev TN J Cardiovasc Electrophysiol. 1997 Jul;8(7):790-802...

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Journal Club – #14

High-resolution fluorescent imaging does not reveal a distinct AV nodal anterior input channel (fast pathway) in the rabbit heart during sinus rhythm Efimov IR, Fahy GJ, Cheng Y, Van Wagoner DR, Tchou PJ, Mazgalev TN J Cardiovasc Electrophysiol. 1997 Mar;8(3):295-306...

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Journal Club – #13

Activation and repolarization patterns are governed by different structural characteristics of ventricular myocardium: experimental study with voltage sensitive dyes and numerical stimulations Efimov IR, Ermentrout B, Huang DT, Salama G J Cardiovasc Electrophysiol....

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Journal Club – #11

Subthreshold stimulation of Purkinje fibers interrupts VT in intact hearts. Experimental study with voltage-sensitive dyes and imaging techniques Salama G, Kanai A, Efimov IR Circulation Research. 1994 Apr; 74(4):604-19...

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Journal Club – #10

Quantification of the transmural dynamics of atrial fibrillation by simultaneous endocardial and epicardial optical mapping in an acute sheep model Sarah R. Gutbrod, Richard Walton, Stephen Gilbert, Valentin Meillet, Pierre Jais, Mélèze Hocini, Michel Haïssaguerre,...

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Journal Club – #9

An activation-repolarization time metric to predict localized regions of high susceptibility to reentry Nicholas Child, Martin J. Bishop, Ben Hanson, Ruben Coronel, Tobias Opthof, Bastiaan J. Boukens, Richard D. Walton, Igor R. Efimov, Julian Bostock, Yoland Hill,...

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Journal Club – #8

The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias Martin J. Bishop, Edward J. Vigmond, Gernot Plank Am J Physiol Heart Circ Physiol 304: H1240-H1252, 2013....

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Journal Club – #7

The role of Purkinje-Myocardial Coupling during Ventricular Arrhythmia: A modeling study Elham Behradfar, Anders Nygren, Edward J. Vigmond PLoS ONE. 2014 Feb 7;9(2):e88000. [PubMed] Attachment: ...

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Journal Club – #6

Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes Jacob I. Laughner, Fu Siong Ng, Matthew S. Sulkin, R. Martin Arthur, Igor R. Efimov Am J Physiol Heart Circ Physiol 303: H753-H765, 2012 [PubMed] Attachment: ...

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Journal Club – #5

Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice Elaine Wan, Jeffrey Adams, Richard L. Weinberg, Alexander N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, Steven O. Marx J Clin Invest....

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Journal Club – #4

Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome Koonlawee Nademanee, Hariharan Raju, Sofia V. de Noronha, Michael Papadkis, Laurence Robinson, Stephen Rothery, Naomasa Makita, Shinya Kowase, Nakorn Boonmee, Vorapot Vitaykritsirikul, Samremg...

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Journal Club – #3

Simultaneous Biatrial High-Density (510-512 Electrodes) Epicardial Mapping of Persistent and Long-Standing Persistent Atrial Fibrillation in Patients: New Insights Into the Mechanism of its Maintenance Seungyup Lee, Jayakumar Sahadevan, Celeen M. Khrestian, Ivan...

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Journal Club – #2

Atrial Fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts Brian J. Hansen, Jichao Zhao, Thomas A. Csepe, Brandon T. Moore, Ning Li, Laura A. Jayne, Anuradha...

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Journal Club – #1

Mapping Cardiac Pacemaker Circuits: Methodologica Puzzles of the Sinoatrial Node Optical Mapping Igor R. Efimov, Vadim V. Fedorov, Boyoung Joung, Shien-Fong Lin Circulation Research. 2010;106:255-271 [PubMed]   Attachment:...

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Our Lab Family Grows

Our Lab Family Grows

Gus Xavier Gloschat was born to Christopher and Lana Gloschat this morning at 4:07 AM. He was 9 days late and weighed 7 pounds 13 ounces. We are happy to announce that both Gus and Lana are happy and...

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Igor Efimov Installed in Collins Professorship

Igor Efimov Installed in Collins Professorship

Igor Efimov, a leader in cardiovascular disease research who joined the George Washington University in January as the first chair of its Department of Biomedical Engineering, was installed as the Alisann and Terry Collins Professor of Biomedical Engineering in a...

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