Kedar Aras, PhD
My vision is to advance scientific understanding of the heart and thus enable quality health care that is affordable and accessible to everyone in need. The mission is to conduct cutting edge translational research in the field of cardiac electrophysiology. The specific goals of my postdoctoral research is to combine experimental, computational and clinical research techniques to:
- Study the mechanisms of various cardiac pathologies including conduction and rhythm disorders such as atrial fibrillation, ventricular fibrillation etc.,
- Develop and validate novel diagnostic tools and strategies for effective anti-arrhythmia therapies
- Provide training and research environment to facilitate cutting edge investigation under the mentorship of Dr. Igor Efimov.
A brief synopsis of the my current research projects is listed below:
- Human Ventricular Arrhythmia Susceptibility: We use donor human hearts that are made available to us for research to investigate the cardiac electrophysiological characteristics including restitution, propagation, wavelength etc., as well susceptibility to ventricular arrhythmia under acute conditions and profile the resulting arrhythmia dynamics such phase singularities, wave breaks etc. The goal of this project is to understand and characterize arrhythmia behavior in actual human hearts that has not been done before.
- High-Definition Chiplet Electronics for Atrial and Ventricular Arrhythmias: Current treatment of ventricular and atrial arrhythmias includes use of implantable cardiac defibrillator (ICD), which is limited by low spatial resolution and results in more often than not inappropriate shocks. We are developing next generation cardiac implantable electrical device (CIED) in collaboration with John Rogers group using the novel conformal, chiplet electronics real time networks (CCERN) for high definition arrhythmia sensing and ultra low energy electrotherapy.
- Structured Light Imaging: Optical mapping technology allows us to study cardiac arrhythmia and defibrillation dynamics in high resolution. However, one limitation of optical mapping technique is the requirement to stop contractile motion of the heart to limit motion artifacts during optical recordings. We are developing next generation panoramic optical mapping technology in collaboration with Song Zhang group using the novel structured light imaging technology that will enable us to acquire simultaneous electrical and mechanical information and thus characterize complete and accurate physiological profile of the heart.
- Ph.D. in Bioengineering, University of Utah, 2015
- Postdoc at George Washington University (2015-present)
- Aras KK, Kay MW, Efimov IR. Ventricular Fibrillation: Rotors or Foci? Both!. Circulation. Arrhythmia and electrophysiology. 2017;10(12). pii: e006011. doi: 10.1161/CIRCEP.117.006011. [PubMed]
- Gloschat CR, Koppel AC, Aras KK, Brennan JA, Holzem KM, Efimov IR.Arrhythmogenic and metabolic remodeling of failing human heart. J Physiol. 2016 Jul 15;594(14):3963-80. doi: 10.1113/JP271992. Epub 2016 Jun 12. [PubMed]
- Aras K, Burton B, Swenson D, MacLeod R. Spatial Organization of Acute Myocardial Ischemia. J Electrocardiology. 2016 Feb 20. pii: S0022-0736(16)00071-6. doi: 10.1016/j.jelectrocard.2016.02.014. [PubMed]
- Aras K, Good W, Tate J, Burton B, Brooks D, Coll-Font J, Doessel O, Schulze W, Potyagaylo D, Wang L, van Dam P, MacLeod R. Experimental Data and Geometric Analysis Repository – EDGAR. J Electrocardiology. 2015 Nov-Dec;48(6):975-81. doi: 10.1016/j.jelectrocard.2015.08.008. Epub 2015 Aug 4. [PubMed]
- Aras K, Burton B, Swenson D, MacLeod R. Sensitivity of epicardial electrical markers to acute ischemia detection. J Electrocardiol. 2014 Nov-Dec;47(6):836-41. doi: 10.1016/j.jelectrocard.2014.08.014. Epub 2014 Aug 17. [PubMed]
- Tate J, Pilcher T, Aras K, Burton B, MacLeod R. Verification of defibrillation simulation using internal electric fields in a human shaped phantom. Comput Cardiol (2010). 2014 Sep 7;2014:689-692. [PubMed]
- Aras K, Swenson D, MacLeod R. Electrographic Response of the Heart to Myocardial Ischemia. Comput Cardiol. 2009;36:105-108. [PubMed]
- Cickovski T, Aras K, Alber MS, Izaguirre JA, Swat M, Glazier JA, Merks RM, Glimm T, Hentschel HG, Newman SA. From genes to organisms via the cell, A problem-solving environment for multicellular development. Comput Sci Eng. 2007;9(4):50-60. [PubMed]