Role of obesity as a local mediator of VT/VF dynamics in Human Ventricles – Kedar Aras

Ventricular tachyarrhythmias are responsible for 300,000 sudden cardiac deaths a year in the US.  In addition, the ever-increasing prevalence of obesity also poses a significant burden on the health care system with increased morbidity and mortality associated with fatal ventricular arrhythmias. In this project, we will a multi-modal and multi-scale approach to characterize how obesity induces ventricular arrhythmias in donor human hearts and use that knowledge to potentially develop new markers to predict and treat ventricular arrhythmias in a clinical setting.