Sex Differences in Human Hearts – Anna Gams

Cardiovascular diseases remain the primary cause of death worldwide. Several epidemiologic and investigative studies have shown the evidence of sex hormones effect on cardiac electrophysiology through genomic regulation. However, very little is known about the molecular basis for gender-related discrepancies in cardiac electrophysiology. In this project, we are developing a platform that looks at tissue level response to the effects of sex hormones and gene expression that aims to improve predictions to sex-dependent drug responses and better diagnosis of cardiac diseases.